How we choose factor VIII to treat hemophilia.

@article{Mannucci2012HowWC,
  title={How we choose factor VIII to treat hemophilia.},
  author={P. Mannucci and M. Mancuso and E. Santagostino},
  journal={Blood},
  year={2012},
  volume={119 18},
  pages={
          4108-14
        }
}
  • P. Mannucci, M. Mancuso, E. Santagostino
  • Published 2012
  • Medicine
  • Blood
  • In high-income countries, the large availability of coagulation factors for replacement therapy of patients with hemophilia A has raised the life expectancy of these lifelong bleeders to that of males from the general population. The practicing clinician is offered a multitude of choices among several commercial brands of factor VIII extracted from human plasma or engineered from mammalian cell cultures by means of recombinant DNA technology. This article has the goal to offer our opinions on… CONTINUE READING
    60 Citations
    The increased demand for plasma-derived factor VIII in Italy.
    • 5
    Emerging drugs for the treatment of hemophilia A and B
    • 7
    Factor VIII products in haemophilia A: one size fits all?
    • 13
    • PDF
    The inhibitors – a challenge for the management of patients with hereditary haemophilia A
    • R. Mihaila
    • Medicine
    • Romanian journal of internal medicine = Revue roumaine de medecine interne
    • 2018
    • PDF
    The history of hemophilia.
    • 19
    2017 Clinical trials update: Innovations in hemophilia therapy
    • 36
    The current and future role of plasma-derived clotting factor concentrate in the treatment of haemophilia A.
    • B. Kevane, N. O'Connell
    • Medicine
    • Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
    • 2018
    • 2
    Evolution of the European guidelines for the clinical development of factor VIII products: little progress towards improved patient management
    • P. Mannucci
    • Medicine
    • Haemophilia : the official journal of the World Federation of Hemophilia
    • 2013
    • 10

    References

    SHOWING 1-10 OF 75 REFERENCES
    Role of von Willebrand factor in immune tolerance induction
    • C. Ettingshausen, W. Kreuz
    • Medicine
    • Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
    • 2005
    • 70
    Back to the future: a recent history of haemophilia treatment
    • P. Mannucci
    • Medicine
    • Haemophilia : the official journal of the World Federation of Hemophilia
    • 2008
    • 151
    Immune tolerance therapy utilizing factor VIII/von Willebrand factor concentrate in haemophilia A patients with high titre factor VIII inhibitors
    • 53
    Hemophilia treatment in developing countries: products and protocols.
    • 26