How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration

@article{Zhou2003HowVB,
  title={How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration},
  author={Aiwu Zhou and James A. Huntington and Navraj S. Pannu and Robin W. Carrell and Randy J Read},
  journal={Nature Structural Biology},
  year={2003},
  volume={10},
  pages={541-544}
}
The interaction of the plasma protein vitronectin with plasminogen activator inhibitor-1 (PAI-1) is central to human health. Vitronectin binding extends the lifetime of active PAI-1, which controls hemostasis by inhibiting fibrinolysis and has also been implicated in angiogenesis. The PAI-1–vitronectin binding interaction also affects cell adhesion and motility. For these reasons, elevated PAI-1 activities are associated both with coronary thrombosis and with a poor prognosis in many cancers… CONTINUE READING

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