How tumour necrosis factor blockers interfere with tuberculosis immunity.

@article{Harris2010HowTN,
  title={How tumour necrosis factor blockers interfere with tuberculosis immunity.},
  author={Julie Harris and Jonathan Keane},
  journal={Clinical and experimental immunology},
  year={2010},
  volume={161 1},
  pages={1-9}
}
Tumour necrosis factor (TNF) is a potent inflammatory cytokine that plays an important role in immunity to numerous bacterial infections, including Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) in humans. Infliximab, adalimumab, certolizumab pegol and etanercept are anti-TNF agents used to treat a range of inflammatory/autoimmune diseases, such as rheumatoid arthritis. The use of some of these drugs has been linked to reactivation TB. In addition to blocking TNF… CONTINUE READING
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