How tumors escape immune destruction and what we can do about it

@article{Gilboa1999HowTE,
  title={How tumors escape immune destruction and what we can do about it},
  author={Eli Gilboa},
  journal={Cancer Immunology, Immunotherapy},
  year={1999},
  volume={48},
  pages={382-385}
}
There is strong circumstantial evidence that tumor progression in cancer patients is controlled by the immune system. As will be detailed below, this conclusion is based on observations that tumor progression is often associated with secretion of immune suppressive factors and/or downregulation of MHC class I antigen presentation functions. The inference is that tumors must have elaborated strategies to circumvent an apparently effective immune response. Importantly, a tumor-specific immune… CONTINUE READING

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