How to treat mania

  title={How to treat mania},
  author={Isabella Pacchiarotti and Gerard Anmella and Lluc Colomer and Eduard Vieta},
  journal={Acta Psychiatrica Scandinavica},
In this paper, we aimed at reviewing evidence‐based treatment options for bipolar mania and proposed tentative evidence‐based clinical suggestions regarding the management of a manic episode, especially regarding the choice of the proper mood stabilizer and antipsychotic medication. 

Existing and emerging pharmacological approaches to the treatment of mania: A critical overview

Manic episodes are a defining, frequent and dramatically disabling occurrence in the course of Bipolar Disorder type I. Current pharmacotherapy of mania lists a good number of agents, but differences

Lithium: about discrepancies between efficacy and clinical use

  • M. Bauer
  • Psychology, Medicine
    Acta psychiatrica Scandinavica
  • 2020
Lithium is an intriguing medication for many reasons: it is a simple trace element found in the periodic table, yet it has demonstrated a unique, striking efficacy in preventing mood episodes in patients with bipolar and unipolar mood disorders.

Cariprazine Use in Combination With a Mood Stabilizer in First Episode Mania

Cariprazine in combination with mood stabilizers proved to be safe and effective in the treatment of FEM with more than half the patients being adherent to treatment, thus minimizing the risk of relapse and improving prognosis.

Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings

BD GWAS risk genes are undoubtedly pivotal resources for modeling this illness, and might be translational therapeutic targets in the future clinical management of BD, and both promising prospects and cautions in utilizing the bulk of useful resources generated by GWAS studies are discussed.



Areas of controversy in neuroprogression in bipolar disorder

Clinical features and biological underpinnings related to neuroprogression in bipolar disorder (BD) and areas of controversy and future research in the field are discussed.

Pharmacological treatment of acute agitation associated with psychotic and bipolar disorder: a systematic review and meta‐analysis

We used systematic review methodology to identify and evaluate short‐term pharmacological interventions for agitation associated with schizophrenia or bipolar disorder.

Efficacy of antimanic treatments in mixed states

McIntyre RS, Yoon J. Efficacy of antimanic treatments in mixed states: A meta-analysis of existing and new treatments for bipolar disorder.

A systematic review of the evidence on the treatment of rapid cycling bipolar disorder

A systematic review of the evidence on the treatment of rapid cycling bipolar disorder and its role in clinical practice is presented.

Inhaled loxapine for agitation revisited: focus on effect sizes from 2 Phase III randomised controlled trials in persons with schizophrenia or bipolar disorder

  • L. Citrome
  • Psychology, Medicine
    International journal of clinical practice
  • 2012
The efficacy of inhaled loxapine for the treatment of agitation associated with schizophrenia or bipolar disorder is described using different examples of effect size (ES).

Intramuscular Aripiprazole in the Acute Management of Psychomotor Agitation

To assess acute efficacy and safety of 9.75 mg of intramuscular (IM) injections of the atypical antipsychiatric aripiprazole in patients with schizophrenia or bipolar disorder and acute agitation.

Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster‐analytic approach

The aim was to examine the heterogeneity of psychosocial outcomes in euthymic bipolar disorder (BD) patients and analyse the potential influence of distinct variables on functioning.

Clozapine As Transformative Treatment In Bipolar Patients

Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder and may become transformative treatment in bipolar disorder impacting the clinical course and psychosocial burden of the disease.

Lithium and suicide in mood disorders: Updated meta‐review of the scientific literature

The best evidence for the effect of lithium on rates of suicide and self harm in mood disorders, particularly bipolar disorders is reviewed.

Mixed states in bipolar and major depressive disorders: systematic review and quality appraisal of guidelines

This systematic review provided a critical synthesis and a comprehensive overview of guidelines on the treatment of mixed states.