How to train your microbe: methods for dynamically characterizing gene networks.

@article{CastilloHair2015HowTT,
  title={How to train your microbe: methods for dynamically characterizing gene networks.},
  author={Sebastian M Castillo-Hair and Oleg A. Igoshin and Jeffrey J. Tabor},
  journal={Current opinion in microbiology},
  year={2015},
  volume={24},
  pages={
          113-23
        }
}
Gene networks regulate biological processes dynamically. However, researchers have largely relied upon static perturbations, such as growth media variations and gene knockouts, to elucidate gene network structure and function. Thus, much of the regulation on the path from DNA to phenotype remains poorly understood. Recent studies have utilized improved genetic tools, hardware, and computational control strategies to generate precise temporal perturbations outside and inside of live cells. These… CONTINUE READING
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Foundations and Emerging Paradigms for Computing in Living Cells.

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