How to study dendrimers and dendriplexes III. Biodistribution, pharmacokinetics and toxicity in vivo.

@article{Shcharbin2014HowTS,
  title={How to study dendrimers and dendriplexes III. Biodistribution, pharmacokinetics and toxicity in vivo.},
  author={Dzmitry Shcharbin and Anna Janaszewska and Barbara Klajnert-Maculewicz and Barbara Ziemba and Volha Dzmitruk and Inessa V. Halets and Svetlana G. Loznikova and Natallia Shcharbina and Katarzyna Milowska and Maksim V. Ionov and Antos Shakhbazau and Maria J Bryszewska},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={181},
  pages={40-52}
}
This paper reviews the biodistribution, toxicity and pharmacokinetics of pure dendrimers and their complexes with nucleic acids (dendriplexes) in animals, including mice, rats, rabbits, and guinea pigs. Methods and results will both be discussed. The paradigm about dendrimers' toxicity based on in vitro studies should be revised; almost all dendrimers of low and middle generations are non-toxic in vivo, despite showing some cytotoxic effects in vitro. Only the high generations of unmodified… CONTINUE READING
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