How to preserve the antidepressive effect of sleep deprivation: A comparison of sleep phase advance and sleep phase delay

  title={How to preserve the antidepressive effect of sleep deprivation: A comparison of sleep phase advance and sleep phase delay},
  author={Dieter Riemann and A. K{\"o}nig and Fritz Hohagen and Andrea Kiemen and Ulrich Voderholzer and Jutta Backhaus and J. Bunz and B. Wesiack and Leopold Hermle and Mathias Berger},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
Abstract Total sleep deprivation (TSD) leads to an immediate amelioration of depressed mood in approximately 70 % of patients with the melancholic subtype of depression. The clinical utility of this procedure is limited, as the improvement usually subsides after the next night of sleep. In the present study, 40 depressed inpatients, being free of psychoactive medication for at least 7 days and who had responded to a TSD were then distributed (according to a matched-pair design) to a sleep phase… 
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