How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?

@inproceedings{Mantilla2018HowTO,
  title={How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?},
  author={Carolina Mantilla and F. A. Saig and J. Cloos and G. Jansen and G. Peters},
  year={2018}
}
P-glycoprotein (ABCB1), multidrug resistance protein-1 (ABCC1) and breast cancer resistance protein (ABCG2) belong to the ATP-binding cassette (ABC) superfamily of proteins that play an important physiological role in protection of the body from toxic xenobiotics and endogenous metabolites. Beyond this, these transporters determine the toxicity profile of many drugs, and confer multidrug resistance (MDR) in cancer cells associated with a poor treatment outcome of cancer patients. It has long… Expand
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