How to measure the diagnostic accuracy of noninvasive liver fibrosis indices: the area under the ROC curve revisited.

@article{Lambert2008HowTM,
  title={How to measure the diagnostic accuracy of noninvasive liver fibrosis indices: the area under the ROC curve revisited.},
  author={J{\^e}rome Lambert and Philippe Halfon and Guillaume Penaranda and Pierre Bedossa and Patrice Cacoub and Fabrice Carrat},
  journal={Clinical chemistry},
  year={2008},
  volume={54 8},
  pages={1372-8}
}
BACKGROUND The area under the ROC curve (AUC) is widely used to measure the diagnostic accuracy of noninvasive fibrosis indices. However, use of the AUC assumes a binary gold standard, whereas fibrosis staging is based on an ordinal scale and also depends on the distribution of fibrosis stages in the study sample. We explored other fibrosis staging accuracy measures designed for ordinal gold standards, the C-statistic and the Obuchowski measure. METHODS We performed a simulation study to… CONTINUE READING

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