How to make a functional β-cell.

@article{Pagliuca2013HowTM,
  title={How to make a functional β-cell.},
  author={Felicia Walton Pagliuca and Douglas A. Melton},
  journal={Development},
  year={2013},
  volume={140 12},
  pages={2472-83}
}
Insulin-secreting pancreatic β-cells are essential regulators of mammalian metabolism. The absence of functional β-cells leads to hyperglycemia and diabetes, making patients dependent on exogenously supplied insulin. Recent insights into β-cell development, combined with the discovery of pluripotent stem cells, have led to an unprecedented opportunity to generate new β-cells for transplantation therapy and drug screening. Progress has also been made in converting terminally differentiated cell… CONTINUE READING
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Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas

  • P. Y. Yi, J. Park, D. M. Melton
  • 2013

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