How to improve R&D productivity: the pharmaceutical industry's grand challenge

@article{Paul2010HowTI,
  title={How to improve R&D productivity: the pharmaceutical industry's grand challenge},
  author={S. Paul and D. Mytelka and C. Dunwiddie and Charles C. Persinger and B. Munos and S. Lindborg and A. Schacht},
  journal={Nature Reviews Drug Discovery},
  year={2010},
  volume={9},
  pages={203-214}
}
  • S. Paul, D. Mytelka, +4 authors A. Schacht
  • Published 2010
  • Medicine, Business
  • Nature Reviews Drug Discovery
  • The pharmaceutical industry is under growing pressure from a range of environmental issues, including major losses of revenue owing to patent expirations, increasingly cost-constrained healthcare systems and more demanding regulatory requirements. In our view, the key to tackling the challenges such issues pose to both the future viability of the pharmaceutical industry and advances in healthcare is to substantially increase the number and quality of innovative, cost-effective new medicines… CONTINUE READING
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    References

    SHOWING 1-10 OF 85 REFERENCES
    The Value of Improving the Productivity of the Drug Development Process
    • J. DiMasi
    • Business, Medicine
    • PharmacoEconomics
    • 2012
    • 128
    Rebuilding the R&D engine in big pharma.
    • 239
    Market Watch: Pharma industry performance metrics: 2007–2012E
    • M. Goodman
    • Medicine
    • Nature Reviews Drug Discovery
    • 2008
    • 10
    The State of Innovation in Drug Development
    • I. Kola
    • Medicine
    • Clinical pharmacology and therapeutics
    • 2008
    • 242