How to improve R&D productivity: the pharmaceutical industry's grand challenge

@article{Paul2010HowTI,
  title={How to improve R\&D productivity: the pharmaceutical industry's grand challenge},
  author={Steven M Paul and Daniel S Mytelka and Christopher T. Dunwiddie and Charles C. Persinger and Bernard H. Munos and Stacy R Lindborg and Aaron Leigh Schacht},
  journal={Nature Reviews Drug Discovery},
  year={2010},
  volume={9},
  pages={203-214}
}
The pharmaceutical industry is under growing pressure from a range of environmental issues, including major losses of revenue owing to patent expirations, increasingly cost-constrained healthcare systems and more demanding regulatory requirements. In our view, the key to tackling the challenges such issues pose to both the future viability of the pharmaceutical industry and advances in healthcare is to substantially increase the number and quality of innovative, cost-effective new medicines… 

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