How to guarantee finding a statistically significant difference: the use and abuse of subgroup analyses

@article{Fayers2009HowTG,
  title={How to guarantee finding a statistically significant difference: the use and abuse of subgroup analyses},
  author={Peter M. Fayers and Madeleine T King},
  journal={Quality of Life Research},
  year={2009},
  volume={18},
  pages={527-530}
}
In 1988 the Lancet published a very large randomised clinical trial of intravenous streptokinase, oral aspirin, both, or neither for treatment of suspected acute myocardial infarction [1]. The ISIS-2 trial recruited 17,187 patients from 417 hospitals. The authors concluded that there were benefits both from streptokinase and from aspirin. This paper contained a complex table reporting subgroup analyses, and rather intriguingly, the first analysis was by astrological birth sign. The results… CONTINUE READING

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Commentary: From star signs to trial guidelines

R. Horton
Lancet • 2000
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