How to escape from model bias with a high-resolution native data set - structure determination of the PcpA-S6 subunit III.

@article{Pignol1996HowTE,
  title={How to escape from model bias with a high-resolution native data set - structure determination of the PcpA-S6 subunit III.},
  author={David Pignol and Christine Gaboriaud and Juan C Fontecilla-Camps and Victor S. Lamzin and Keith S Wilson},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={1996},
  volume={52 Pt 2},
  pages={345-55}
}
The structure of procarboxypeptidase A-S6 subunit III, a truncated zymogen E, has been determined by molecular replacement using as search model porcine elastase 1 which, as revealed by crystallographic analysis, contained about 20% of the amino acids in a radically different orientation. Two monoclinic crystal forms were used: the first one diffracts to 2… CONTINUE READING