• Corpus ID: 6104912

How to design multi-target drugs: Target search options in cellular networks

@article{Korcsmros2007HowTD,
  title={How to design multi-target drugs: Target search options in cellular networks},
  author={Tam{\'a}s Korcsm{\'a}ros and Mate S. Szalay and Csaba Bode and Istv{\'a}n A. Kov{\'a}cs and P{\'e}ter Csermely},
  journal={arXiv: Molecular Networks},
  year={2007}
}
Despite improved rational drug design and a remarkable progress in genomic, proteomic and high-throughput screening methods, the number of novel, single-target drugs fell much behind expectations during the past decade. Multi-target drugs multiply the number of pharmacologically relevant target molecules by introducing a set of indirect, network-dependent effects. Parallel with this the low-affinity binding of multi-target drugs eases the constraints of druggability, and significantly increases… 
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