How to deal with parameters for whole-cell modelling.

@article{Babtie2017HowTD,
  title={How to deal with parameters for whole-cell modelling.},
  author={Ann C. Babtie and Michael P. H. Stumpf},
  journal={Journal of the Royal Society, Interface},
  year={2017},
  volume={14 133}
}
Dynamical systems describing whole cells are on the verge of becoming a reality. But as models of reality, they are only useful if we have realistic parameters for the molecular reaction rates and cell physiological processes. There is currently no suitable framework to reliably estimate hundreds, let alone thousands, of reaction rate parameters. Here, we map out the relative weaknesses and promises of different approaches aimed at redressing this issue. While suitable procedures for estimation… CONTINUE READING

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