How to become neural crest: from segregation to delamination.

  title={How to become neural crest: from segregation to delamination.},
  author={Aixa V. Morales and Julio A. Barbas and Miguel Nieto},
  journal={Seminars in cell & developmental biology},
  volume={16 6},
The development of the neural crest up to the stage where they leave the neural tube can be observed as a series of concatenated but independent events that involve dorsalization of the neural plate/neural tube, neural crest induction, segregation and stabilization, epithelial to mesenchymal transition and delamination. During all these processes, the nascent neural crest cells are subjected to the influence of different signals and have to overcome competition for cell fate and apoptotic… CONTINUE READING