How to Ward Off Retinal Toxicity of Perfluorooctane and Other Perfluorocarbon Liquids?

@article{Menz2018HowTW,
  title={How to Ward Off Retinal Toxicity of Perfluorooctane and Other Perfluorocarbon Liquids?},
  author={Dirk-henning Menz and Nicolas Feltgen and Helge Menz and Bernd-Kristof M{\"u}ller and Thorsten Lechner and Joachim Hans Dresp and Hans Hoerauf},
  journal={Investigative ophthalmology & visual science},
  year={2018},
  volume={59 12},
  pages={
          4841-4846
        }
}
Purpose Reactive and underfluorinated impurities are acknowledged as a source of cytotoxicity of perfluorocarbon liquids (PFCLs) used as blood substitutes. To determine whether this is also a relevant factor in retinal toxicity, we analyzed eight PFO batches associated with adverse ocular events. Methods (A) The amount of reactive and underflurinated impurities was analyzed by fluoride-selective potentiometry and expressed as H-value. (B) Cytotoxicity of these batches was determined by an ISO… CONTINUE READING

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Towards Better Safety Standards for Vitreoretinal Medical Devices.

  • Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
  • 2018

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