How to Understand the Cell by Breaking It: Network Analysis of Gene Perturbation Screens

@inproceedings{Markowetz2010HowTU,
  title={How to Understand the Cell by Breaking It: Network Analysis of Gene Perturbation Screens},
  author={Florian Markowetz},
  booktitle={PLoS Computational Biology},
  year={2010}
}
Modern high-throughput gene perturbation screens are key technologies at the forefront of genetic research. Combined with rich phenotypic descriptors they enable researchers to observe detailed cellular reactions to experimental perturbations on a genome-wide scale. This review surveys the current stateof-the-art in analyzing single gene perturbation… CONTINUE READING