How to Understand the Cell by Breaking It: Network Analysis of Gene Perturbation Screens

  title={How to Understand the Cell by Breaking It: Network Analysis of Gene Perturbation Screens},
  author={Florian Markowetz},
  journal={PLoS Computational Biology},
  • F. Markowetz
  • Published 15 October 2009
  • Biology
  • PLoS Computational Biology
Functional genomics has demonstratedconsiderable success in inferring the innerworking of a cell through analysis of itsresponse to various perturbations. Inrecent years several technological advanc-es have pushed gene perturbation screensto the forefront of functional genomics.Most importantly, modern technologiesmake it possible to probe gene function ona genome-wide scale in many modelorganisms and human. For example, largecollections of knock-out mutants play aprominent role in the study of… 

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