How to Turn the Reaction Coordinate into Time


What are the internal motions of an ion channel protein when it “gates” between closed and open-channel conformations? In 2005, Zhou, Pearson, and Auerbach (ZPA) (Biophys. J. 89:3680–3685) showed that Φ, a parameter derived from the forward and backward rate constants of a chemical reaction, may in some cases provide temporal information about the moving… (More)


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