How thymic antigen presenting cells sample the body's self-antigens.

  title={How thymic antigen presenting cells sample the body's self-antigens.},
  author={Jens M. Derbinski and Bruno Kyewski},
  journal={Current opinion in immunology},
  volume={22 5},
Our perception of the scope self-antigen availability for tolerance induction in the thymus has profoundly changed over the recent years following new insights into the cellular and molecular complexity of intrathymic antigen presentation. The diversity of self-peptide display is on the one hand afforded by the remarkable heterogeneity of thymic antigen presenting cells (APCs) and on the other hand by the endowment of these cells with unconventional molecular pathways. Recent studies show that… CONTINUE READING
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Byersdorfer CA, Unanue ER: Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction

  • DF Atibalentja
  • J Immunol
  • 2009

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