How theories evolved concerning the mechanism of action of barbiturates

@article{Lscher2012HowTE,
  title={How theories evolved concerning the mechanism of action of barbiturates},
  author={W. L{\"o}scher and M. Rogawski},
  journal={Epilepsia},
  year={2012},
  volume={53}
}
The barbiturate phenobarbital has been in use in the treatment of epilepsy for 100 years. It has long been recognized that barbiturates act by prolonging and potentiating the action of γ‐aminobutyric acid (GABA) on GABAA receptors and at higher concentrations directly activating the receptors. A large body of data supports the concept that GABAA receptors are the primary central nervous system target for barbiturates, including the finding that transgenic mice with a point mutation in the β3… Expand
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Introduction
Phenobarbital, 5-ethyl-5-phenyl barbituric acid, was introduced to treat epilepsy in 1912. Phenobarbital was the second barbiturate in clinical use, following barbital’s (Veronal, or 5,5-diethylExpand
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GABAA receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation
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