How theories evolved concerning the mechanism of action of barbiturates.

@article{Lscher2012HowTE,
  title={How theories evolved concerning the mechanism of action of barbiturates.},
  author={Wolfgang L{\"o}scher and Michael A Rogawski},
  journal={Epilepsia},
  year={2012},
  volume={53 Suppl 8},
  pages={
          12-25
        }
}
  • Wolfgang Löscher, Michael A Rogawski
  • Published in Epilepsia 2012
  • Medicine
  • The barbiturate phenobarbital has been in use in the treatment of epilepsy for 100 years. It has long been recognized that barbiturates act by prolonging and potentiating the action of γ-aminobutyric acid (GABA) on GABA(A) receptors and at higher concentrations directly activating the receptors. A large body of data supports the concept that GABA(A) receptors are the primary central nervous system target for barbiturates, including the finding that transgenic mice with a point mutation in the… CONTINUE READING

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