How theories evolved concerning the mechanism of action of barbiturates

  title={How theories evolved concerning the mechanism of action of barbiturates},
  author={W. L{\"o}scher and M. Rogawski},
  • W. Löscher, M. Rogawski
  • Published 2012
  • Chemistry, Medicine
  • Epilepsia
  • The barbiturate phenobarbital has been in use in the treatment of epilepsy for 100 years. It has long been recognized that barbiturates act by prolonging and potentiating the action of γ‐aminobutyric acid (GABA) on GABAA receptors and at higher concentrations directly activating the receptors. A large body of data supports the concept that GABAA receptors are the primary central nervous system target for barbiturates, including the finding that transgenic mice with a point mutation in the β3… CONTINUE READING
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