How the study of Helicobacter infection can contribute to the understanding of carcinoma development.

  title={How the study of Helicobacter infection can contribute to the understanding of carcinoma development.},
  author={C. Stoicov and H. Li and J. Cerny and J. Houghton},
  journal={Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases},
  volume={15 9},
  • C. Stoicov, H. Li, +1 author J. Houghton
  • Published 2009
  • Biology, Medicine
  • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
The inflammatory environment dramatically impacts the formation of cancer at many levels, acting on the stem cell to foster the initiation of cancer all the way through its contribution to metastatic disease. Using Helicobacter-induced gastric cancer as an example, it can be seen that, early on, chronic inflammation exhausts tissue stem cells, forcing the remaining stem cells to work overtime and calling in replacement cells from marrow sources. Marrow-derived stromal cells orchestrate growth… Expand
Statins’ Regulation of the Virulence Factors of Helicobacter pylori and the Production of ROS May Inhibit the Development of Gastric Cancer
Conventionally, statins are used to treat high cholesterol levels. They exhibit pleiotropic effects, such as the prevention of cardiovascular disease and decreased cancer mortality. Gastric cancerExpand
Mesenchymal Stem Cells Utilize CXCR4–SDF-1 Signaling for Acute, but Not Chronic, Trafficking to Gastric Mucosal Inflammation
The results show that MSC have a tumorigenic effect by promoting an accelerated form of gastric cancer in mice, and the engraftment of MSC in chronic inflammation is only partially CXCR4-dependent. Expand
Circulating cytokines and gastric cancer risk
Examination of pre-diagnostic systemic cytokine levels in plasma and risk of distal gastric cancer in a case–control study nested within the prospective Shanghai Men’s Health Study found increased circulating levels of IL-8 may indicate increased risk of Gastric cancer. Expand
Clinical consequences of Helicobacter pylori infection in children and its relation with the response of the gastric mucosa to the infection
It can be concluded that the gastric mucosa of children actively responds to the presence of H. pylori, which may partly be responsible for the required "immune training" needed to protect for the development of esophageal cancer, asthma, allergy or even diabetes later in life. Expand
Histopathologic features of esophageal glands in the region of the gastroesophageal junction in Chinese patients with gastric cardiac cancer involving the esophagus
A spectrum of histopathologic changes in EGs and ductile epithelium is demonstrated, which is similar to those observed in GCE in Chinese patients. Expand
Variation in human genetic polymorphisms, their association with Helicobacter pylori acquisition and gastric cancer in a multi‐ethnic country
The association between polymorphisms related to immune and cancer‐related pathways and H. pylori infection among the major ethnicities, Chinese, Malay and Indian, resident in Singapore and Malaysia as well as the association between these polymorphisms and GC development in ethnic Chinese patients are investigated. Expand


The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease.
There is accumulating evidence that long-term treatment with cyclo-oxygenase inhibitors, cytokines such as interferon-alpha, anti-oestrogens (tamoxifen and raloxifene) and captopril significantly reduces the incidence of solid tumours such as breast and colorectal cancer. Expand
Inflammation and cancer: back to Virchow?
A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided. Expand
Prospective identification of tumorigenic prostate cancer stem cells.
The identification and characterization of a cancer stem cell population from human prostate tumors, which possess a significant capacity for self-renewal and are able to regenerate the phenotypically mixed populations of nonclonogenic cells, which express differentiated cell products. Expand
Gastric Cancer Originating from Bone Marrow-Derived Cells
It is shown that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter induces repopulation of the stomach with BMDCs, suggesting that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression. Expand
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
It is demonstrated that bone-marrow-derived human mesenchymal stem cells, when mixed with otherwise weakly metastatic human breast carcinoma cells, cause the cancer cells to increase their metastatic potency greatly when this cell mixture is introduced into a subcutaneous site and allowed to form a tumour xenograft. Expand
Inflammation, atrophy, and gastric cancer.
  • J. Fox, T. Wang
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2007
An overview of recent progress in elucidating the bacterial properties responsible for colonization of the stomach, persistence in the stomach and triggering of inflammation, as well as the host factors that have a role in determining whether gastritis progresses to gastric cancer are provided. Expand
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
The inflammatory chemoattractants S 100A8 and S100A9, whose expression is induced by distant primary tumours, attract Mac 1-myeloid cells in the premetastatic lung and may be common to both myeloid cell recruitment and tumour-cell invasion. Expand
Stem cells in normal breast development and breast cancer
A new in vitro culture system is developed that permits, for the first time, the propagation of mammary stem and progenitor cells in an undifferentiated state, which should facilitate the elucidation of pathways that regulate normal mammarystem-cell self-renewal and differentiation. Expand
CXCR4 Activation Induces Epidermal Growth Factor Receptor Transactivation in an Ovarian Cancer Cell Line
It is shown that SDF‐1α induces proliferation in ovarian cancer cells in a dose‐dependent manner and it is demonstrated that the SDF-1‐dependent proliferation correlates to the phosphorylation and activation of extracellular signal‐regulated kinases (ERK)1/2, which in turn are correlated to epidermal growth factor (EGF) receptor transactivation. Expand
On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease
Diverse functions of TNF/TNFRs are placed into context with the development of specific pathology in murine models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease to suggest that TNF may also directly promote or downregulate the adaptive immune response. Expand