How the cerebral serotonin homeostasis predicts environmental changes: a model to explain seasonal changes of brain 5-HTT as intermediate phenotype of the 5-HTTLPR

@article{Kalbitzer2013HowTC,
  title={How the cerebral serotonin homeostasis predicts environmental changes: a model to explain seasonal changes of brain 5-HTT as intermediate phenotype of the 5-HTTLPR},
  author={J. Kalbitzer and U. Kalbitzer and G. Knudsen and P. Cumming and A. Heinz},
  journal={Psychopharmacology},
  year={2013},
  volume={230},
  pages={333-343}
}
  • J. Kalbitzer, U. Kalbitzer, +2 authors A. Heinz
  • Published 2013
  • Biology, Medicine
  • Psychopharmacology
  • Molecular imaging studies with positron emission tomography have revealed that the availability of serotonin transporter (5-HTT) in the human brain fluctuates over the course of the year. This effect is most pronounced in carriers of the short allele of the 5-HTT promoter region (5-HTTLPR), which has in several previous studies been linked to an increased risk to develop mood disorders. We argue that long-lasting fluctuations in the cerebral serotonin transmission, which is regulated via the 5… CONTINUE READING
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