How the Intestinal Peptide Transporter PEPT-1 Contributes to an Obesity Phenotype in Caenorhabditits elegans

@inproceedings{Spanier2009HowTI,
  title={How the Intestinal Peptide Transporter PEPT-1 Contributes to an Obesity Phenotype in Caenorhabditits elegans},
  author={Britta Spanier and Katrin Lasch and Silke Marsch and Jacqueline Benner and Wenjuan Liao and Hao Hu and Hermine Kienberger and Wolfgang Eisenreich and Hannelore Daniel},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Amino acid absorption in the form of di- and tripeptides is mediated by the intestinal proton-coupled peptide transporter PEPT-1 (formally OPT-2) in Caenorhabditits elegans. Transporter-deficient animals (pept-1(lg601)) show impaired growth, slowed postembryonal development and major changes in amino acid status. PRINCIPAL FINDINGS Here we demonstrate that abolished intestinal peptide transport also leads to major metabolic alterations that culminate in a two fold increase in total… CONTINUE READING