How the Confocal Laser Scanning Microscope entered Biological Research

  title={How the Confocal Laser Scanning Microscope entered Biological Research},
  author={William Bradshaw Amos and J. G. White},
  journal={Biology of the Cell},
  • W. Amos, J. G. White
  • Published 1 September 2003
  • Biology, Medicine, Engineering
  • Biology of the Cell
A history of the early development of the confocal laser scanning microscope in the MRC Laboratory of Molecular Biology in Cambridge is presented. [...] Key Result The key innovations were the scanning of the light beam over the specimen rather than vice-versa and a high magnification at the level of the detector, allowing the use of a macroscopic iris. These were followed by an achromatic all-reflective relay system, a non-confocal transmission detector and novel software for control and basic image processing…Expand
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