How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA.

Abstract

The POT1-TPP1 heterodimer, the major telomere-specific single-stranded DNA-binding protein in mammalian cells, protects chromosome ends and contributes to the regulation of telomerase. The recent discovery of telomeric RNA raises the question of how POT1 faithfully binds telomeric ssDNA and avoids illicit RNA binding that could result in its depletion from… (More)
DOI: 10.1073/pnas.0911099107

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@article{Nandakumar2010HowTP, title={How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA.}, author={Jayakrishnan Nandakumar and Elaine R. Podell and Thomas R Cech}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2010}, volume={107 2}, pages={651-6} }