How structural features influence the biomembrane permeability of peptides.

  title={How structural features influence the biomembrane permeability of peptides.},
  author={Philip S. Burton and Robert A. Conradi and Norman F. H. Ho and Allen R. Hilgers and Ronald T. Borchardt},
  journal={Journal of pharmaceutical sciences},
  volume={85 12},
Successful drug development requires not only optimization of specific and potent pharmacological activity at the target site, but also efficient delivery to that site. Many promising new peptides with novel therapeutic potential for the treatment of AIDS, cardiovascular diseases, and CNS disorders have been identified, yet their clinical utility has been limited by delivery problems. Along with metabolism, a major factor contributing to the poor bioavailability of peptides is thought to be… CONTINUE READING


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