How stress and fluoxetine modulate serotonin 2C receptor pre-mRNA editing.

@article{Englander2005HowSA,
  title={How stress and fluoxetine modulate serotonin 2C receptor pre-mRNA editing.},
  author={Michael Thomas Englander and Stephanie C. Dulawa and Punita Bhansali and C Schmauss},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 3},
  pages={
          648-51
        }
}
In two inbred strains of mice, C57BL/6 and 129Sv, the majority of forebrain neocortical pre-mRNA encoding the serotonin 2C (5-HT2C) receptor is altered by adenosine-to-inosine editing. As a result, >60% of all mRNAs encode receptors with reduced constitutive and agonist-stimulated activity. However, in the BALB/c strain, a genetically distinct inbred strain with lower forebrain serotonin levels, spontaneously elevated anxiety, and increased stress reactivity, the majority of 5-HT2C mRNA is… CONTINUE READING

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Effects of chronic fluoxetine in animal models of anxiety and depression

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