Corpus ID: 236428357

How sticky are our proteins? Quantifying hydrophobicity of the human proteome

  title={How sticky are our proteins? Quantifying hydrophobicity of the human proteome},
  author={Juami Hermine Mariama van Gils and Dea Gogishvili and J. A. van Eck and Robbin Bouwmeester and Erik van Dijk and Sanne Abeln},
Proteins tend to bury hydrophobic residues inside their core during the folding process to provide stability to the protein structure and to prevent aggregation. Nevertheless, proteins do expose some ’sticky’ hydrophobic residues to the solvent. These residues can play an important functional role, for example in protein-protein and membrane interactions. Here, we investigate how hydrophobic protein surfaces are by providing three measures for surface hydrophobicity: the total hydrophobic… Expand

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