How small changes led to big profits for insulin manufacturers

@article{Cohen2010HowSC,
  title={How small changes led to big profits for insulin manufacturers},
  author={Deborah Cohen and Philip Carter},
  journal={BMJ : British Medical Journal},
  year={2010},
  volume={341}
}
In the first of a series of investigations by the BMJ and Channel 4 News, Deborah Cohen and Philip Carter discover why more expensive analogue insulins are increasingly prescribed instead of cheaper human insulin despite lack of evidence of benefit for patients with type 2 diabetes 
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  • D. Spence
  • Medicine
  • BMJ : British Medical Journal
  • 2013
TLDR
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Meta‐analysis of individual patient data to assess the risk of hypoglycaemia in people with type 2 diabetes using NPH insulin or insulin glargine
Aim: To estimate absolute and relative incidence rates of hypoglycaemia when using once‐daily evening or morning regimens of insulin glargine (glargine) versus once‐daily evening NPH insulin (NPH)Expand
Cost-effectiveness of insulin analogues for diabetes mellitus
TLDR
Routine use of insulin analogues, especially long-acting analogues in type 2 diabetes, is unlikely to represent an efficient use of finite health care resources and depends on the type of insulin analogue and whether the patient receiving the treatment has type 1 or type 1 diabetes. Expand
Nice insulins, pity about the evidence
In February 2006 the German Institute for Quality and Efficiency in Healthcare (IQWiG), an independent body with a mandate to assess the evidence for medical interventions, released its final reportExpand
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How the market in diabetes has changed over the past 10 years is described and how it might change over the next 5 years is considered. Expand
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TLDR
The clinical effectiveness and cost-effectiveness of using CSII to treat diabetes and to update the previous assessment report by reviewing evidence that has emerged since the last appraisal, and to take account of developments in alternative therapies, in particular the long-acting analogue insulins. Expand
Similar progression of diabetic retinopathy with insulin glargine and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes: a long-term, randomised, open-label study
TLDR
This study shows no evidence of a greater risk of the development or progression of diabetic retinopathy with insulin glargine vs NPH insulin treatment in patients with type 2 diabetes mellitus. Expand
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TLDR
NovoSol Basal seems to be an appreciable advance over Ultratard HM as a soluble insulin preparation for obtaining reproducible 24 hour insulin concentrations in the blood. Expand
Top 15 global therapeutic classes
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Type 2 diabetes: the management of type 2 diabetes. Clinical guideline 66
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