How slippage-derived sequences are incorporated into rRNA variable-region secondary structure: implications for phylogeny reconstruction.

@article{Hancock2000HowSS,
  title={How slippage-derived sequences are incorporated into rRNA variable-region secondary structure: implications for phylogeny reconstruction.},
  author={John M. Hancock and Alfried P Vogler},
  journal={Molecular phylogenetics and evolution},
  year={2000},
  volume={14 3},
  pages={
          366-74
        }
}
We analyzed the type and frequency of mutational changes in hypervariable rRNA regions, using the highly length-variable region V4 of the small subunit rRNA locus of tiger beetles (Cicindelidae) as an example. Phylogenetic analysis of indels in closely related species showed that (1) most indels are single nucleotides (usually A or T and sometimes G) or di-nucleotides of A and T. These occur at numerous foci, and they exhibit a strong bias for duplication of 5' single and di-nucleotide motifs… CONTINUE READING

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