How should we move the field of chemopreventive agent development forward in a productive manner?

@article{Meyskens2005HowSW,
  title={How should we move the field of chemopreventive agent development forward in a productive manner?},
  author={Frank L. Meyskens and Eva Szab{\'o}},
  journal={Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer},
  year={2005},
  volume={166},
  pages={113-24}
}
Epidemiologic observations and preclinical experimental investigations suggest that the prevention or reversal of precancers should be an effective strategy in humans to control cancer. Although "proof of principle" has been established in humans, the results of randomized trials have not been confirmatory in most cases. Toxicity in normal or near-normal populations has also been greater than anticipated. We examine the problems associated with testing chemoprevention agents in humans and offer… CONTINUE READING

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