How selection affects phenotypic fluctuation

  title={How selection affects phenotypic fluctuation},
  author={Yoichiro Ito and Hitoshi Toyota and Kunihiko Kaneko and Tetsuya Yomo},
  journal={Molecular Systems Biology},
  pages={264 - 264}
The large degree of phenotypic fluctuation among isogenic cells highlighted by recent studies on stochastic gene expression confers fitness on some individuals through a 'bet-hedging' strategy, when faced with different selective environments. Under a single selective environment, the fluctuation may be suppressed through evolution, as it prevents maintenance of individuals around the fittest state and/or function. However, as fluctuation can increase phenotypic diversity, similar to mutation… CONTINUE READING

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