How safe are the xenogeneic hemostats? — Report of a case of severe systemic allergic reaction

@article{Kitamura1995HowSA,
  title={How safe are the xenogeneic hemostats? — Report of a case of severe systemic allergic reaction},
  author={Kazuya Kitamura and Rie Yasuoka and Miyakatsu Ohara and Masataka Shimotsuma and Akeo Hagiwara and Tetsuro Yamane and Toshiharu Yamaguchi and Toshio Takahashi},
  journal={Surgery Today},
  year={1995},
  volume={25},
  pages={433-435}
}
We report herein the unusual case of a 55-year-old woman who developed a severe systemic allergy to Avitene (microfibrillar collagen hydrochloride), a xenogeneic agent sometimes used for topical hemostasis in laparoscopic cholecystectomy. The patient developed fever, general fatigue, mild liver dysfuction, and prominent eosinophilia postoperatively. A skin allergy test confirmed that these abnormal findings were attributable to an allergic reaction to Avitene. 

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