How ricin and Shiga toxin reach the cytosol of target cells: retrotranslocation from the endoplasmic reticulum.


A number of protein toxins bind at the surface of mammalian cells and after endocytosis traffic to the endoplasmic reticulum, where the toxic A chains are liberated from the holotoxin. The free A chains are then dislocated, or retrotranslocated, across the ER membrane into the cytosol. Here, in contrast to ER substrates destined for proteasomal destruction… (More)
DOI: 10.1007/82_2011_154


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