How renal cytokines and growth factors contribute to renal disease progression.

@article{Benigni2001HowRC,
  title={How renal cytokines and growth factors contribute to renal disease progression.},
  author={Ariela Benigni and Giuseppe Remuzzi},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2001},
  volume={37 1 Suppl 2},
  pages={S21-4}
}
Terminal renal failure is the final common fate of chronic nephropathies regardless of the type of original insult. After removal of a critical number of nephrons, adaptive hemodynamic changes in the remaining nephrons ensure enough filtration power to the kidney but are ultimately detrimental. Such changes are largely mediated by the local formation of angiotensin II (AII) and prevented by the use of angiotensin-converting enzyme inhibitors, which also limit the forced opening of large… CONTINUE READING

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