How regulatory T cells work

@article{Vignali2008HowRT,
  title={How regulatory T cells work},
  author={Dario Angelo Alberto Vignali and Lauren West Collison and Creg J Workman},
  journal={Nature Reviews Immunology},
  year={2008},
  volume={8},
  pages={523-532}
}
Regulatory T (TReg) cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit beneficial responses by suppressing sterilizing immunity and limiting antitumour immunity. Given that TReg cells can have both beneficial and deleterious effects, there is considerable interest in determining their mechanisms of action. In this Review, we describe the basic mechanisms used by TReg cells to mediate… CONTINUE READING
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