How principles of domain formation in model membranes may explain ambiguities concerning lipid raft formation in cells.

@article{London2005HowPO,
  title={How principles of domain formation in model membranes may explain ambiguities concerning lipid raft formation in cells.},
  author={Erwin London},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1746 3},
  pages={203-20}
}
Sphingolipid and cholesterol-rich liquid ordered lipid domains (lipid rafts) have been studied in both eukaryotic cells and model membranes. However, while the coexistence of ordered and disordered liquid phases can now be easily demonstrated in model membranes, the situation in cell membranes remains ambiguous. Unlike the usual situation in model membranes, under most conditions, cell membranes rich in sphingolipid and cholesterol may have a "granular" organization in which the size of ordered… CONTINUE READING