How possible is the prevention of polycystic ovary syndrome development in adolescent patients with early onset of hyperandrogenism

@article{Apter1998HowPI,
  title={How possible is the prevention of polycystic ovary syndrome development in adolescent patients with early onset of hyperandrogenism},
  author={D. Apter},
  journal={Journal of Endocrinological Investigation},
  year={1998},
  volume={21},
  pages={613-617}
}
  • D. Apter
  • Published 1998
  • Medicine
  • Journal of Endocrinological Investigation
The polycystic ovary syndrome has a pubertal onset, with menstrual cycle irregularities and infertility in adulthood, as well as general health hazards such as increased risk for diabetes mellitus and myocardial infarction. Thus, prevention would be important. But as specific etiological factors are not known, nor is specific intervention. In order to use long-term intervention programs in children and adolescents, particularly rigid criteria must be used regarding proven safety and efficacy… Expand
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Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism.
TLDR
Hyperinsulinemia with normal fasting glucose levels in HA girls may reflect insulin resistance, as suggested by the increased ratio of insulin and glucose (P < 0.01), and decreased insulin sensitivity was related to other factors in addition to BMI. Expand
Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome
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The purpose of this study was to examine the effect of long‐term calorie restriction on clinical as well as biochemical abnormalities in obese women with polycystic ovary syndrome. Expand
Clinical, endocrinologic, and ultrasonographic features of polycystic ovary syndrome in Singaporean adolescents.
TLDR
The current opinion is that adolescents with PCOS should be managed early, and that treatment should include medical correction of any hormonal or body-weight imbalance and include psychologic intervention when necessary. Expand
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TLDR
Assessment of basal LH levels and the LH/FSH ratio in hyperandrogenic anovulatory women are clinically meaningful when BMI is taken into account and the diagnostic value of LH determinations is retained for PCOS women with BMI < 30 kg/m2. Expand
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TLDR
Current evidence regarding the basis for the dysfunction of ovarian steroidogenesis and follicular maturation, and the aberration of gonadotropin secretion as related to the inappropriate steroid feedback system will be reviewed. Expand
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TLDR
It is concluded that weight loss is beneficial in all obese hyper androgenic women regardless of the presence of polycystic ovaries, the degree of hyperandrogenism, and the degree and distribution of obesity. Expand
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TLDR
The data suggest that PCO is primarily a disorder of the ovary and that the observed gonadotropin abnormalities are secondary to the ovarian lesion. Expand
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TLDR
It is concluded that polycystic ovarian syndrome is a disorder with perimenarchal onset, the clinical, endocrine and ultrasound features of which will not change by age, although patients are prone to gain weight as they get older. Expand
Postmenarchal evolution of endocrine pattern and ovarian aspects in adolescents with menstrual irregularities.
TLDR
It is suggested that, despite persistent irregular cycles, some adolescents normalize all endocrine and ovarian parameters toward maturity, while subjects with persistent irregular anovulatory cycles maintain marked hyperandrogenism, increasingly high LH values, and enlarged multicystic ovaries. Expand
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TLDR
Responses of 17-OHP to leuprolide acetate challenge facilitate the identification of FOH patients, establish this test as a reliable diagnostic tool in FOH diagnosis, and confirm the ovaries as the source of hyperandrogenemia in most patients with androgen excess. Expand
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