How phenobarbital revolutionized epilepsy therapy: The story of phenobarbital therapy in epilepsy in the last 100 years

@article{Yasiry2012HowPR,
  title={How phenobarbital revolutionized epilepsy therapy: The story of phenobarbital therapy in epilepsy in the last 100 years},
  author={Zeid Yasiry and S. Shorvon},
  journal={Epilepsia},
  year={2012},
  volume={53}
}
  • Zeid Yasiry, S. Shorvon
  • Published 2012
  • Medicine
  • Epilepsia
  • Phenobarbital (phenobarbitone) was first used as an antiepileptic drug 100 years ago, in 1912. This article tells the story of the discovery of its antiepileptic action, its early development, and the subsequent course of its clinical use over the 100‐year period. The side effects, pharmacokinetics, and misuse of barbiturates are considered, along with the more recent clinical trials and the drug’s current clinical utilization. The introduction of controlled drug regulations, the comparative… CONTINUE READING
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