How oocytes try to get it right: spindle checkpoint control in meiosis

@article{Touati2015HowOT,
  title={How oocytes try to get it right: spindle checkpoint control in meiosis},
  author={Sandra A. Touati and Katja Wassmann},
  journal={Chromosoma},
  year={2015},
  volume={125},
  pages={321-335}
}
The generation of a viable, diploid organism depends on the formation of haploid gametes, oocytes, and spermatocytes, with the correct number of chromosomes. Halving the genome requires the execution of two consecutive specialized cell divisions named meiosis I and II. Unfortunately, and in contrast to male meiosis, chromosome segregation in oocytes is error prone, with human oocytes being extraordinarily “meiotically challenged”. Aneuploid oocytes, that are with the wrong number of chromosomes… CONTINUE READING
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