How often does the ratchet click? Facts, heuristics, asymptotics

  title={How often does the ratchet click? Facts, heuristics, asymptotics},
  author={Alison M. Etheridge and Peter Pfaffelhuber and Anton Wakolbinger},
The evolutionary force of recombination is lacking in asexually reproducing populations. As a consequence, the population can suffer an irreversible accumulation of deleterious mutations, a phenomenon known as Muller's ratchet. We formulate discrete and continuous time versions of Muller's ratchet. Inspired by Haigh's (1978) analysis of a dynami-cal system which arises in the limit of large populations, we identify the parameter γ = N λ/(N s · log(N λ)) as most important for the speed of… CONTINUE READING

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