How nascent phagosomes mature to become phagolysosomes.

  title={How nascent phagosomes mature to become phagolysosomes.},
  author={Gregory D Fairn and Sergio Grinstein},
  journal={Trends in immunology},
  volume={33 8},
Phagocytosis mediates the clearance of apoptotic bodies and also the elimination of microbial pathogens. The nascent phagocytic vacuole formed upon particle engulfment lacks microbicidal and degradative activity. These capabilities are acquired as the phagosome undergoes maturation; a progressive remodeling of its membrane and contents that culminates in the formation of phagolysosomes. Maturation entails orderly sequential fusion of the phagosomal vacuole with specialized endocytic and… CONTINUE READING
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