How much surface coating of hydrophobic azithromycin is sufficient to prevent moisture-induced decrease in aerosolisation of hygroscopic colistin powder ?

@inproceedings{Zhou2018HowMS,
  title={How much surface coating of hydrophobic azithromycin is sufficient to prevent moisture-induced decrease in aerosolisation of hygroscopic colistin powder ?},
  author={Qi Zhou and Zhi Hui Loh and Jiaqi Yu and Si-ping Sun and Thomas Gengenbach and A. John and Denman and Jian Kang Li and Hak-kim Chan},
  year={2018}
}
Aerosolisation performance of hygroscopic particles of colistin could be compromised at elevated humidity due to increased capillary forces. Co-spray drying colistin with a hydrophobic drug is known to provide a protective coating on the composite particle surfaces against moisture-induced reduction in aerosolisation performance; however, the effects of component ratio on surface coating quality and powder aerosolisation at elevated relative humidities are unknown. In this study, we have… CONTINUE READING

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