How much difference does chromosome banding make? Adjustments in prevalence and mutation rates of human structural cytogenetic abnormalities.

@article{Hook1989HowMD,
  title={How much difference does chromosome banding make? Adjustments in prevalence and mutation rates of human structural cytogenetic abnormalities.},
  author={Ernest B. Hook and Noel Healy and Andrea Willey},
  journal={Annals of human genetics},
  year={1989},
  volume={53 Pt 3},
  pages={237-42}
}
A collaborative analysis was undertaken of 226 karyotypes with structural chromosome abnormalities diagnosed primarily with low level banding resolution, about 300 to 400 bands per karyotype. We estimate that in this series, use of low level banding was required to detect about 78% of pericentric inversions, about 51% of reciprocal translocations, about 47% of all balanced translocations, about 35% of unbalanced rearrangements other than rings, Robertsonian translocations and extra structurally… CONTINUE READING