• Biology, Medicine
• Published in The Biochemical journal 2009
• DOI:10.1042/BJ20081386

How mitochondria produce reactive oxygen species

@inproceedings{Murphy2009HowMP,
  title={How mitochondria produce reactive oxygen species},
  author={Michael P Murphy},
  booktitle={The Biochemical journal},
  year={2009}
}

• Michael P Murphy

The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the cytosol and nucleus. Superoxide (O2(*-)) is the proximal mitochondrial ROS, and in the present review I outline the principles that govern O2(*-) production within the matrix of mammalian mitochondria. The flux of O2(*-) is related to the concentration of potential electron donors… CONTINUE READING

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