How mitochondria produce reactive oxygen species

  title={How mitochondria produce reactive oxygen species},
  author={M. Murphy},
  journal={Biochemical Journal},
  pages={1 - 13}
  • M. Murphy
  • Published 2009
  • Medicine, Biology
  • Biochemical Journal
  • The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the cytosol and nucleus. [...] Key Result Two modes of operation by isolated mitochondria result in significant O2(*-) production, predominantly from complex I: (i) when the mitochondria are not making ATP and consequently have a high Deltap (protonmotive force) and a reduced CoQ (coenzyme Q) pool…Expand Abstract
    4,759 Citations

    Paper Mentions

    Interventional Clinical Trial
    Objectives: The research focus of the study is the production of reactive oxygen species (ROS) in patients with type 2 diabetes (T2D) in response to glutathione (GSH) supplementation… Expand
    ConditionsMitochondrial Reactive Oxygen Species Production, Oxidative Stress, Type 2 Diabetes
    InterventionDietary Supplement, Other
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