How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans.


The human microbiota, which plays an important role in health and disease, uses complex carbohydrates as a major source of nutrients. Utilization hierarchy indicates that the host glycosaminoglycans heparin (Hep) and heparan sulfate (HS) are high-priority carbohydrates for Bacteroides thetaiotaomicron, a prominent member of the human microbiota. The… (More)
DOI: 10.1073/pnas.1704367114


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