How matrix metalloproteinases regulate cell behavior.

@article{Sternlicht2001HowMM,
  title={How matrix metalloproteinases regulate cell behavior.},
  author={Mark D. Sternlicht and Zena Werb},
  journal={Annual review of cell and developmental biology},
  year={2001},
  volume={17},
  pages={
          463-516
        }
}
  • M. Sternlicht, Z. Werb
  • Published 2001
  • Biology, Medicine
  • Annual review of cell and developmental biology
The matrix metalloproteinases (MMPs) constitute a multigene family of over 25 secreted and cell surface enzymes that process or degrade numerous pericellular substrates. Their targets include other proteinases, proteinase inhibitors, clotting factors, chemotactic molecules, latent growth factors, growth factor-binding proteins, cell surface receptors, cell-cell adhesion molecules, and virtually all structural extracellular matrix proteins. Thus MMPs are able to regulate many biologic processes… 
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Several MMPs have been shown to act as key agonists during tumor invasion, metastasis, and angiogenesis, thus raising the possible clinical utility of inhibiting select M MPs during early as well as late stages of cancer progression.
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