How many signals impinge on GLUT4 activation by insulin?

  title={How many signals impinge on GLUT4 activation by insulin?},
  author={Aibin He and Xiaojun Liu and Lizhong Liu and Yongsheng Chang and Fude Fang},
  journal={Cellular signalling},
  volume={19 1},
GLUT4 is the main glucose transporter activated by insulin in skeletal muscle cells and adipocytes. GLUT4 storage vesicles (GSVs) traffic in endocytic and exocytic compartments. In the basal state, GLUT4 compartments are preferentially sequestered in perinuclear deposits wherein stimuli including insulin and non-insulin factors can increase GLUT4 vesicle formation, its exocytosis, and fusion to plasma membrane. In addition to well-established effectors of insulin signaling pathway, such as… CONTINUE READING


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